Title |
Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart
|
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Published in |
Memórias do Instituto Oswaldo Cruz, July 2001
|
DOI | 10.1590/s0074-02762001000500017 |
Pubmed ID | |
Authors |
Moacir Paranhos-Silva, Lain C Pontes-de-Carvalho, Geraldo G de Sá Oliveira, Eliane Góes Nascimento, Washington LC dos-Santos |
Abstract |
Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a large proportion of dogs (11 out of 56) examined in an endemic area of leishmaniasis presented induration at the site of injection of a diluent containing thimerosal alone. This clearly demonstrates that thimerosal leads to a high number of false positive skin reactions in dogs and that its use in Montenegro's skin test antigenic preparations should be avoided. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 17% |
Researcher | 4 | 13% |
Other | 3 | 10% |
Professor > Associate Professor | 3 | 10% |
Student > Bachelor | 2 | 7% |
Other | 8 | 27% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 30% |
Agricultural and Biological Sciences | 5 | 17% |
Veterinary Science and Veterinary Medicine | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Immunology and Microbiology | 2 | 7% |
Other | 2 | 7% |
Unknown | 6 | 20% |