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Clinical forms of Trypanosoma cruzi infected individuals in the chronic phase of Chagas disease in Puebla, Mexico

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, November 2006
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Title
Clinical forms of Trypanosoma cruzi infected individuals in the chronic phase of Chagas disease in Puebla, Mexico
Published in
Memórias do Instituto Oswaldo Cruz, November 2006
DOI 10.1590/s0074-02762006000700005
Pubmed ID
Authors

María del Carmen Sánchez-Guillén, Aurelio López-Colombo, Guillermo Ordóñez-Toquero, Isidoro Gomez-Albino, Judith Ramos-Jimenez, Enrique Torres-Rasgado, Hilda Salgado-Rosas, Mónica Romero-Díaz, Patricia Pulido-Pérez, Ricardo Pérez-Fuentes

Abstract

In Mexico, despite the relatively high seroprevalence of Trypanosoma cruzi infection in humans in some areas, reported morbidity of Chagas disease is not clear. We determined clinical stage in 71 individuals seropositive to T. cruzi in the state of Puebla, Mexico, an area endemic for Chagas disease with a reported seroprevalence of 7.7%. Diagnosis of Chagas disease was made by two standardized serological tests (ELISA, IHA). Individuals were stratified according to clinical studies. All patients were submitted to EKG, barium swallow, and barium enema. Groups were identified as indeterminate form (IF) asymptomatic individuals without evidence of abnormalities (n = 34 cases); those with gastrointestinal alterations (12 patients) including symptoms of abnormal relaxation of the lower esophageal sphincter and absent peristalsis in the esophageal body, grade I megaesophagus, and/or megacolon; patients with clinical manifestations and documented changes of chronic Chagas heart disease who were subdivided as follows: mild (8 patients)--mild electrocardiographic changes of ventricular repolarization, sinus bradychardia); moderate (6 patients)--left bundle branch block, right bundle branch block associated with left anterior fascicular block); severe (8 patients)--signs of cardiomegaly, dilated cardiomyopathy); and the associated form (3 cases) that included presence of both cardiomyopathy and megaesophagus. These data highlight the importance of accurate evaluation of the prevalence and clinical course of Chagas disease in endemic and non-endemic areas of Mexico.

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Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Colombia 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 17%
Student > Ph. D. Student 10 13%
Student > Master 9 12%
Student > Doctoral Student 8 11%
Student > Bachelor 5 7%
Other 13 17%
Unknown 17 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 21%
Medicine and Dentistry 16 21%
Biochemistry, Genetics and Molecular Biology 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Immunology and Microbiology 4 5%
Other 10 13%
Unknown 19 25%