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Characterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, February 2000
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  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 1,254)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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3 Google+ users

Citations

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44 Mendeley
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Title
Characterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice
Published in
Brazilian Journal of Medical and Biological Research, February 2000
DOI 10.1590/s0100-879x2000000200002
Pubmed ID
Authors

R.I. Vázquez-Padrón, L. Moreno-Fierros, L. Neri-Bazán, A.F. Martínez-Gil, G.A. de-la-Riva, R. López-Revilla

Abstract

The present paper describes important features of the immune response induced by the Cry1Ac protein from Bacillus thuringiensis in mice. The kinetics of induction of serum and mucosal antibodies showed an immediate production of anti-Cry1Ac IgM and IgG antibodies in serum after the first immunization with the protoxin by either the intraperitoneal or intragastric route. The antibody fraction in serum and intestinal fluids consisted mainly of IgG1. In addition, plasma cells producing anti-Cry1Ac IgG antibodies in Peyer's patches were observed using the solid-phase enzyme-linked immunospot (ELISPOT). Cry1Ac toxin administration induced a strong immune response in serum but in the small intestinal fluids only anti-Cry1Ac IgA antibodies were detected. The data obtained in the present study confirm that the Cry1Ac protoxin is a potent immunogen able to induce a specific immune response in the mucosal tissue, which has not been observed in response to most other proteins.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Mexico 1 2%
Iceland 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 25%
Student > Bachelor 7 16%
Researcher 6 14%
Student > Ph. D. Student 5 11%
Professor 4 9%
Other 7 16%
Unknown 4 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 50%
Biochemistry, Genetics and Molecular Biology 6 14%
Environmental Science 4 9%
Immunology and Microbiology 2 5%
Chemistry 2 5%
Other 6 14%
Unknown 2 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 430. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2022.
All research outputs
#66,339
of 25,374,917 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#1
of 1,254 outputs
Outputs of similar age
#36
of 111,372 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#1
of 13 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,254 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,372 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.