Title |
Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12
|
---|---|
Published in |
Brazilian Journal of Medical and Biological Research, October 2001
|
DOI | 10.1590/s0100-879x2001001000002 |
Pubmed ID | |
Authors |
A.A. Camargo, D.N. Nunes, H.B. Samaia, L. Liu, V.P. Collins, A.J.G. Simpson, E. Dias-Neto |
Abstract |
DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 27% |
Other | 2 | 13% |
Student > Master | 2 | 13% |
Researcher | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 33% |
Medicine and Dentistry | 3 | 20% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Neuroscience | 1 | 7% |
Engineering | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 27% |