Title |
Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications
|
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Published in |
Brazilian Journal of Medical and Biological Research, April 2008
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DOI | 10.1590/s0100-879x2008005000016 |
Pubmed ID | |
Authors |
B.A. Cardoso, A. Gírio, C. Henriques, L.R. Martins, C. Santos, A. Silva, J.T. Barata |
Abstract |
T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular intracellular signaling pathways. Despite very significant improvements, current therapeutic regimens still fail to cure a portion of the patients and frequently implicate the use of aggressive protocols with long-term side effects. In this review, we focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-beta, may contribute to T-ALL. Identifying the alterations that affect intracellular pathways that regulate cell cycle and apoptosis is essential to understanding the biology of this malignancy, to define more effective markers for the correct stratification of patients into appropriate therapeutic regimens and to identify novel targets for the development of specific, less detrimental therapies for T-ALL. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 2% |
China | 1 | 2% |
Belarus | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 30% |
Student > Ph. D. Student | 8 | 17% |
Student > Master | 7 | 15% |
Professor > Associate Professor | 4 | 9% |
Student > Postgraduate | 3 | 6% |
Other | 4 | 9% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 34% |
Medicine and Dentistry | 9 | 19% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Immunology and Microbiology | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 2 | 4% |
Unknown | 8 | 17% |