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Mendeley readers
| Title |
Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation of the skin? An experimental study1
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|---|---|
| Published in |
Acta Cirúrgica Brasileira, August 2015
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| DOI | 10.1590/s0102-865020150080000002 |
| Pubmed ID | |
| Authors |
Jose Octavio Gonçalves de Freitas, Paulo Rogério Quieregatto, Bernardo Hochman, Guilherme Abbud Franco Lapin, Stella Maria Botequio Mella, Jessica Ruivo Maximino, Gerson Chadi, Lydia Masako Ferreira |
| Abstract |
To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats. Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were performed 30 minutes prior to the surgical skin incision and tissue collection. SP and CGRP (15 kDa pro-CGRP and 5 kDa CGRP) were quantified by Western Blotting. No statistically significant differences (p>0.05) were found in pro-CGRP, CGRP and SP values in all three groups. The anti-inflammatory effect of dexamethasone did not occur when the substance P and calcitonin gene-related peptide levels were altered during the neurogenic inflammation process of skin wound healing in rats. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 24% |
| Student > Bachelor | 3 | 18% |
| Student > Ph. D. Student | 2 | 12% |
| Student > Master | 2 | 12% |
| Other | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 24% |
| Medicine and Dentistry | 2 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Nursing and Health Professions | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 6 | 35% |