Title |
Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study1
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Published in |
Acta Cirúrgica Brasileira, January 2016
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DOI | 10.1590/s0102-865020160010000010 |
Pubmed ID | |
Authors |
Müge Arıkan, Bilge Aslan, Osman Arıkan, Eyüp Horasanlı, Abdulkadir But |
Abstract |
To compare the effects of magnesium sulfate and ketamine on postoperative pain and total morphine consumption in a placebo-controlled design. One hundred and twenty women scheduled for total abdominal hysterectomy were included in this prospective, randomized, double-blind study. Postoperatively, when the Numeric Pain Rating Scale (NPRS) was four or more, IV-PCA morphine was applied to all patients. The patients were randomized into three groups: Group K ketamine, Group M magnesium, and Group C saline received as infusion. Total morphine consumption for 48h, pain scores, adverse effects, and patients' satisfaction were evaluated. Total morphine consumption was significantly lower in Group K (32.6±9.2 mg) than in Group M (58.9±6.5 mg) and in Group C (65.7±8.2 mg). The satisfaction level of patients in Group K was higher than the other two groups (p<0.05). Pruritus and nausea were observed more frequently in Group C. CONCLUSİON: The addition of ketamine to IV-PCA morphine reduces the total consumption of morphine without psychotic effects; however, magnesium did not influence morphine consumption. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 87 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 14% |
Student > Master | 10 | 11% |
Researcher | 9 | 10% |
Other | 8 | 9% |
Student > Doctoral Student | 6 | 7% |
Other | 17 | 20% |
Unknown | 25 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 29 | 33% |
Nursing and Health Professions | 8 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
Psychology | 4 | 5% |
Agricultural and Biological Sciences | 3 | 3% |
Other | 7 | 8% |
Unknown | 30 | 34% |