Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats1

Eros Luiz de Sousa, Antônio Felipe Paulino de Figueiredo Wouk, Osvaldo Malafaia, Jurandir Marcondes Ribas-Filho, Lucia Noronha, Silvana Maris Cirio, Claudia Turra PimpãoVII, Carlos Hespanha Marinho, Maria Fernanda Torres, Yorgos Luiz Santos de Salles Graça, Daniel Dantas Ferrarin

To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use. Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9. Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods. The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.