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Analysis of gene expression EGFR and KRAS, microRNA-21 and microRNA-203 in patients with colon and rectal cancer and correlation with clinical outcome and prognostic factors1

Overview of attention for article published in Acta Cirúrgica Brasileira, March 2017
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Title
Analysis of gene expression EGFR and KRAS, microRNA-21 and microRNA-203 in patients with colon and rectal cancer and correlation with clinical outcome and prognostic factors1
Published in
Acta Cirúrgica Brasileira, March 2017
DOI 10.1590/s0102-865020170030000009
Pubmed ID
Authors

Thais Inácio de Carvalho, Paulo Cezar Novais, Fermino Sanches Lizarte, Renata Danielle Sicchieri, Marcella Suelma Torrecillas Rosa, Camila Albuquerque Mello de Carvalho, Daniela Pretti da Cunha Tirapelli, Fernanda Maris Peria, José Joaquim Ribeiro da Rocha, Omar Féres

Abstract

To evaluate the expression of EGFR, KRAS genes, microRNAs-21 and 203 in colon and rectal cancer samples, correlated with their age at diagnosis, histological subtype, value of pretreatment CEA, TNM staging and clinical outcome. Expression of genes and microRNAs by real time PCR in tumor and non-tumor samples obtained from surgical treatment of 50 patients. An increased expression of microRNAs-21 and 203 in tumor samples in relation to non-tumor samples was found. There was no statistically significant difference between the expression of these genes and microRNAs when compared to age at diagnosis and histological subtype. The EGFR gene showed higher expression in relation to the value of CEA diagnosis. The expression of microRNA-203 was progressively lower in relation to the TNM staging and was higher in the patient group in clinical remission. The therapy of colon and rectum tumors based on microRNAs remains under investigation reserving huge potential for future applications and clinical interventions in conjunction with existing therapies. We expect, based on the exposed data, to stimulate the development of new therapeutic possibilities, making the treatment of these tumors more effective.

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Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Student > Master 5 18%
Student > Bachelor 3 11%
Researcher 3 11%
Student > Doctoral Student 1 4%
Other 0 0%
Unknown 10 36%
Readers by discipline Count As %
Medicine and Dentistry 6 21%
Biochemistry, Genetics and Molecular Biology 5 18%
Agricultural and Biological Sciences 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Nursing and Health Professions 1 4%
Other 2 7%
Unknown 11 39%