Report for: Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects

Title	Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects
Published in	Anais Brasileiros de Dermatologia, April 2012
DOI	10.1590/s0365-05962012000100013
Pubmed ID	22481658
Authors	Renata Aparecida Martinez Antunes Ribeiro Vieira, Eliana Maria Minicucci, Mariangela Esther Alencar Marques, Silvio Alencar Marques
Abstract	Actinic cheilitis is the main precancerous lesion of the lip. Squamous cell carcinoma of the lip is reported together with oral carcinomas in the Brazilian official statistics. Overall, they account for 40% of the head and neck carcinomas. In general, physicians and dentists know little about what causes oral tumor development and progression. Tumor suppressor genes and cell proliferation regulatory proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. Knowledge on prognostic and diagnostic markers has a positive impact on the follow-up of these patients.

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Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects