Title |
Staphylococcus aureus bacteremia: comparison of two periods and a predictive model of mortality
|
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Published in |
Brazilian Journal of Infectious Diseases, December 2002
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DOI | 10.1590/s1413-86702002000600004 |
Pubmed ID | |
Authors |
Lucieni de Oliveira Conterno, Sérgio Barsanti Wey, Adauto Castelo |
Abstract |
Staphylococcus aureus is an important pathogen causing bacteremia, primarily affecting hospitalized patients. We studied the epidemiology of S. aureus bacteremia, comparing two periods (early and mid 1990s) and developed a predictive model of mortality. A nested case-control was done. All 251 patients over 14 years old with positive blood cultures for S. aureus were selected. MRSA (methicillin resistant S. aureus) was isolated in 63% of the cases. When comparing the two periods MRSA community-acquired bacteremia increased from 4% to 16% (p=0.01). There was no significant difference in the mortality rate between the two periods (39% and 33%, p=0.40). Intravascular catheters provoked 24% of the cases of bacteremia and were associated with the lowest rate of mortality. In a logistic regression analysis, three variables were associated with death: septic shock, source of bacteraemia and resistance to methicillin. The probability of dying among patients with MRSA and those with methicillin sensitive S. aureus bacteraemia ranged from 10% to 90% and from 4% to 76%, respectively, depending on the source of the bacteraemia and the occurrence of septic shock. The MRSA found in Brazil may be a particularly virulent strain. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 21% |
Researcher | 5 | 18% |
Student > Bachelor | 4 | 14% |
Student > Doctoral Student | 3 | 11% |
Professor | 2 | 7% |
Other | 6 | 21% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 43% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 11% |
Nursing and Health Professions | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 3 | 11% |
Unknown | 5 | 18% |