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Combination of meta-analysis and graph clustering to identify prognostic markers of ESCC

Overview of attention for article published in Genetics and Molecular Biology, June 2012
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Title
Combination of meta-analysis and graph clustering to identify prognostic markers of ESCC
Published in
Genetics and Molecular Biology, June 2012
DOI 10.1590/s1415-47572012000300021
Pubmed ID
Authors

Hongyun Gao, Lishan Wang, Shitao Cui, Mingsong Wang

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most malignant gastrointestinal cancers and occurs at a high frequency rate in China and other Asian countries. Recently, several molecular markers were identified for predicting ESCC. Notwithstanding, additional prognostic markers, with a clear understanding of their underlying roles, are still required. Through bioinformatics, a graph-clustering method by DPClus was used to detect co-expressed modules. The aim was to identify a set of discriminating genes that could be used for predicting ESCC through graph-clustering and GO-term analysis. The results showed that CXCL12, CYP2C9, TGM3, MAL, S100A9, EMP-1 and SPRR3 were highly associated with ESCC development. In our study, all their predicted roles were in line with previous reports, whereby the assumption that a combination of meta-analysis, graph-clustering and GO-term analysis is effective for both identifying differentially expressed genes, and reflecting on their functions in ESCC.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 20%
Researcher 2 13%
Other 2 13%
Student > Doctoral Student 1 7%
Lecturer 1 7%
Other 5 33%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 4 27%
Biochemistry, Genetics and Molecular Biology 3 20%
Computer Science 3 20%
Engineering 2 13%
Social Sciences 1 7%
Other 1 7%
Unknown 1 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2012.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Genetics and Molecular Biology
#551
of 771 outputs
Outputs of similar age
#138,715
of 177,625 outputs
Outputs of similar age from Genetics and Molecular Biology
#12
of 22 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 771 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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