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Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans

Overview of attention for article published in Genetics and Molecular Biology, July 2012
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Title
Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans
Published in
Genetics and Molecular Biology, July 2012
DOI 10.1590/s1415-47572012005000048
Pubmed ID
Authors

Valeria Peralta-Leal, Evelia Leal-Ugarte, Juan P. Meza-Espinoza, Ingrid P. Dávalos-Rodríguez, Anabel Bocanegra-Alonso, Rosa I. Acosta-González, Enrique Gonzales, Saraswathy Nair, Jorge Durán-González

Abstract

The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy-Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 19%
Student > Bachelor 5 14%
Student > Doctoral Student 3 8%
Researcher 3 8%
Professor > Associate Professor 2 6%
Other 3 8%
Unknown 13 36%
Readers by discipline Count As %
Medicine and Dentistry 5 14%
Psychology 5 14%
Biochemistry, Genetics and Molecular Biology 4 11%
Unspecified 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 4 11%
Unknown 15 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2012.
All research outputs
#16,046,765
of 25,373,627 outputs
Outputs from Genetics and Molecular Biology
#344
of 771 outputs
Outputs of similar age
#109,001
of 178,782 outputs
Outputs of similar age from Genetics and Molecular Biology
#6
of 18 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 771 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,782 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.