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Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis

Overview of attention for article published in Genetics and Molecular Biology, September 2014
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Title
Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis
Published in
Genetics and Molecular Biology, September 2014
DOI 10.1590/s1415-47572014000400001
Pubmed ID
Authors

Xiaoyang Liao, Zhiyi Yang, Daqing Peng, Hua Dai, Yi Lei, Qian Zhao, Yanbing Han, Weiwen Wang

Abstract

The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google Scholar. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Ultimately, nine eligible studies, including 2188 essential hypertension cases and 2459 controls, were enrolled in this meta-analysis. No significant associations were found under the overall ORs for M-allele comparison (M vs. T, pooled OR 0.92, 95% CI 0.62-1.37), MM vs. TT (pooled OR 0.86, 95% CI 0.29-2.51), TM vs. TT n (pooled OR 0.91, 95% CI 0.63-1.32), recessive model (MM vs. TT+TM, pooled OR 0.89, 95% CI 0.35-2.30), dominant model (MM+TM vs. TT, pooled OR 0.91, 95% CI 0.60-1.38) between T174M polymorphism and risk for essential hypertension. This meta-analysis suggested that the T174M polymorphism of the angiotensinogen gene might not be associated with the susceptibility of essential hypertension in Asian or European populations.

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Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 30%
Student > Master 2 20%
Lecturer 1 10%
Unknown 4 40%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 30%
Environmental Science 1 10%
Social Sciences 1 10%
Medicine and Dentistry 1 10%
Unknown 4 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2014.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Genetics and Molecular Biology
#647
of 771 outputs
Outputs of similar age
#224,333
of 262,419 outputs
Outputs of similar age from Genetics and Molecular Biology
#11
of 12 outputs
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