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Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat

Overview of attention for article published in Brazilian Journal of Microbiology, June 2015
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Title
Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat
Published in
Brazilian Journal of Microbiology, June 2015
DOI 10.1590/s1517-838246220131278
Pubmed ID
Authors

Yuanhong Xie, Hongxing Zhang, Hui Liu, Lixia Xiong, Xiuzhi Gao, Hui Jia, Zhengxing Lian, Nengsheng Tong, Tao Han

Abstract

To investigate the effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rats, female Wistar rats were fed a high-cholesterol diet (HCD) for 28 d to generate hyperlipidemic models. Hyperlipidemic rats were assigned to four groups, which were individually treated with three different dosages of K. marxianus M3+HCD or physiological saline+HCD via oral gavage for 28 d. The total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels in the serum and liver of the rats were measured using commercially available enzyme kits. In addition, the liver morphology was also examined using hematoxylin and eosin staining and optical microscopy. According to our results, the serum and liver TC, TG, LDL-C levels and atherogenic index (AI) were significantly decreased in rats orally administered K. marxianus M3 (p <0.01), and the HDL-C levels and anti atherogenic index (AAI) were significantly increased (p <0.01) compared to the control group. Moreover, K. marxianus M3 treatment also reduced the build-up of lipid droplets in the liver and exhibited normal hepatocytes, suggesting a protective effect of K. marxianus M3 in hyperlipidemic rats.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 20%
Student > Bachelor 6 15%
Researcher 5 13%
Other 4 10%
Student > Postgraduate 4 10%
Other 7 18%
Unknown 6 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 30%
Agricultural and Biological Sciences 9 23%
Medicine and Dentistry 5 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Chemical Engineering 1 3%
Other 3 8%
Unknown 8 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2016.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Brazilian Journal of Microbiology
#1,047
of 1,377 outputs
Outputs of similar age
#240,027
of 281,412 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#36
of 45 outputs
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