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The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial

Overview of attention for article published in International Brazilian Journal of Urology, January 2015
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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Title
The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial
Published in
International Brazilian Journal of Urology, January 2015
DOI 10.1590/s1677-5538.ibju.2015.02.07
Pubmed ID
Authors

Ali Cyrus, Ali Kabir, Davood Goodarzi, Mehrdad Moghimi

Abstract

Varicocele is one of the most common causes of male infertility and spontaneous pregnancy rate after varicocelectomy is only about 30%. The most important seminal antioxidant is vitamin C but recent studies about the effects of vitamin C on spermatogenesis are controversial; therefore, we decided to evaluate its role after varicocelectomy. In a double blind randomized controlled clinical trial, 115 men with infertility and clinical varicocele with abnormal semen analyses were recruited. After surgery, the intervention group received vitamin C (250 mg bid) and the control group received placebo for three months. Mean sperm count, motility, and morphology index of two semen analyses (before and after surgery) were compared between the two groups. Univariate general linear model and stepwise linear regression were used in analysis. The mean age (±SD) of participants was 27.6±5.3 years. Vitamin C group had statistically significant better normal motility (20.8 vs. 12.6, P=0.041) and morphology (23.2 vs. 10.5, P<0.001) than placebo group. Considering the values prior to surgery as covariate, vitamin C was not effective on sperm count (P=0.091); but it improved sperm motility (P=0.016) and morphology (P<0.001) even after excluding the confounding effect of age (P=0.044 and P=0.001, respectively). Vitamin C was also an independent factor in predicting motility and normal morphology after surgery. Ascorbic acid can play a role as adjuvant treatment after varicocelectomy in infertile men.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 109 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 21 19%
Student > Bachelor 11 10%
Other 10 9%
Researcher 8 7%
Student > Doctoral Student 4 4%
Other 17 15%
Unknown 39 35%
Readers by discipline Count As %
Medicine and Dentistry 37 34%
Biochemistry, Genetics and Molecular Biology 7 6%
Nursing and Health Professions 5 5%
Agricultural and Biological Sciences 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 10 9%
Unknown 44 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2018.
All research outputs
#8,474,955
of 25,374,917 outputs
Outputs from International Brazilian Journal of Urology
#169
of 726 outputs
Outputs of similar age
#109,477
of 359,538 outputs
Outputs of similar age from International Brazilian Journal of Urology
#12
of 58 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 726 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,538 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.