Title |
Moderate or severe LUTS is associated with increased recurrence of non - muscle - invasive urothelial carcinoma of the bladder
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Published in |
International Brazilian Journal of Urology, April 2019
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DOI | 10.1590/s1677-5538.ibju.2018.0068 |
Pubmed ID | |
Authors |
Austin Lunney, Allan Haynes, Pranav Sharma |
Abstract |
Non - muscle - invasive bladder cancer (NMIBC) can recur despite transurethral resection (TURBT) and adjuvant intravesical therapy. Tobacco products excreted in the urine are hypothesized to cause tumor - promoting effects on urothelial cells through direct contact. We determined if moderate or severe lower urinary tract symptoms (LUTS) (defined as International Prostate Symptom Score [IPSS] ≥ 8) was associated with increased tumor recurrence. We retrospectively identified 70 consecutive men initially diagnosed with NMIBC at our institution from 2010 - 2016. Means were compared with independent T - test and proportions with chi - square analysis. Multivariate logistic regression was performed to determine independent predictors of recurrence. The majority of patients had Ta disease (58.6%) followed by T1 (28.6%) and Tis (12.9%). Forty - one (58.6%) patients had moderate or severe LUTS upon presentation within 30 days of initial TURBT with mean IPSS of 13.2 vs. 5.2 in the control group (p < 0.01). Biopsy - proven tumor recurrence occurred in 24 (34.3%) patients at mean follow-up of 31.7 months. Mean time to recurrence was 14.6 months. Moderate or severe LUTS was an independent predictor of tumor recurrence (odds ratio [OR]: 19.1, 95% confidence interval [CI]: 2.86 - 127; p = 0.002). Voiding or storage symptoms based on the IPSS did not independently correlate with tumor recurrence (p = 0.08 and p = 0.31, respectively) although total mean IPSS score did (OR: 1.26, 95% CI: 1.07 - 1.47, p = 0.005). The presence of moderate or severe LUTS may be an important prognostic factor in NMIBC. Patients with significant urinary symptoms could be monitored more aggressively due to higher recurrence risk. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 19% |
Student > Bachelor | 3 | 19% |
Researcher | 3 | 19% |
Other | 2 | 13% |
Student > Postgraduate | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Social Sciences | 1 | 6% |
Materials Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 8 | 50% |