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Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, July 2018
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Title
Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, July 2018
DOI 10.1590/s1678-9946201860035
Pubmed ID
Authors

Débora Dinelly de Sousa, Claudiane Raquel de Sousa Silva, Wilson Pereira Lima, Jacqueline de Aguiar Barros, Ismael Alexandre da Silva Nascimento, Victor Costa de Souza, Felipe Gomes Naveca, Fabiana Granja

Abstract

Hepatitis B virus (HBV) infection is a serious global health problem. HBV has a high viral genetic diversity, with 10 genotypes recognized. In Brazil, the Roraima State is the third in the Northern region regarding the number of hepatitis B cases. On the other hand, few data on HBV genotyping and phylogenetic analysis are available. The purpose of this study is to characterize the HBV genotypes circulating in Roraima State. Of the 113 chronic hepatitis B patients enrolled in this study, 40 were HBV-DNA positive. A fragment of 280 bp (S gene) was amplified by PCR and submitted to nucleotide sequencing. A dataset containing the viral sequences obtained in this study, plus 130 obtained from GenBank was used for genotyping by phylogenetic analysis. The HBV subgenotype distribution found was A1 (62.5%), A2 (7.5%), D2, D3, D4 (2.5%), F2a (12.5%), and F3 (10%). We characterized the genotypes and subgenotypes of HBV circulating among patients in the State of Roraima. In addition, our study shows for the first time the HBV/F3 genotype circulating in Brazil. In conclusion, our findings showed a high diversity of HBV genotypes in Roraima, which is also found in other Brazilian geographical regions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 16%
Student > Bachelor 3 12%
Researcher 3 12%
Student > Postgraduate 2 8%
Student > Ph. D. Student 2 8%
Other 3 12%
Unknown 8 32%
Readers by discipline Count As %
Medicine and Dentistry 4 16%
Agricultural and Biological Sciences 3 12%
Environmental Science 1 4%
Nursing and Health Professions 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 5 20%
Unknown 10 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2018.
All research outputs
#17,292,294
of 25,385,509 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#433
of 785 outputs
Outputs of similar age
#219,880
of 340,393 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#6
of 10 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 785 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,393 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.