Title |
Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice
|
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Published in |
Einstein (São Paulo), September 2011
|
DOI | 10.1590/s1679-45082011ao2013 |
Pubmed ID | |
Authors |
Wendy Caroline de Souza Costa França, Ana Cláudia Rodrigues Lopes Amaral de Souza, José Antônio Cordeiro, Patricia Maluf Cury |
Abstract |
To evaluate the effect of janaguba in inhibiting the development of lung cancer in an experimental urethane-induced model. a total of 3mg/kg urethane was injected in 51 Balb-C mice aged 7-13 weeks of life. Janaguba was administered orally daily in two doses: 0.04 mL (Group 2, G2) and 0.06 mL (Group 3, G3), for 20 weeks. After this period, the mice were sacrificed and the number of lesions counted. The mean weight of Group 2 was lower than that of Group 3, and that of Group 1 (Control, G1) (G1 = 35.533 g; G2 = 33.359 g; G3 = 37.125 g). The number of nodules did not differ between groups (mean G1 = G2 = G3 = 1; p = 0.88). Janaguba had an effect on the growth of mice, but had no influence on the progression of lung cancer in this model. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 2 | 33% |
Student > Postgraduate | 1 | 17% |
Other | 1 | 17% |
Student > Master | 1 | 17% |
Unknown | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 50% |
Environmental Science | 1 | 17% |
Veterinary Science and Veterinary Medicine | 1 | 17% |
Unknown | 1 | 17% |