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Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice

Overview of attention for article published in Einstein (São Paulo), September 2011
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Title
Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice
Published in
Einstein (São Paulo), September 2011
DOI 10.1590/s1679-45082011ao2013
Pubmed ID
Authors

Wendy Caroline de Souza Costa França, Ana Cláudia Rodrigues Lopes Amaral de Souza, José Antônio Cordeiro, Patricia Maluf Cury

Abstract

To evaluate the effect of janaguba in inhibiting the development of lung cancer in an experimental urethane-induced model. a total of 3mg/kg urethane was injected in 51 Balb-C mice aged 7-13 weeks of life. Janaguba was administered orally daily in two doses: 0.04 mL (Group 2, G2) and 0.06 mL (Group 3, G3), for 20 weeks. After this period, the mice were sacrificed and the number of lesions counted. The mean weight of Group 2 was lower than that of Group 3, and that of Group 1 (Control, G1) (G1 = 35.533 g; G2 = 33.359 g; G3 = 37.125 g). The number of nodules did not differ between groups (mean G1 = G2 = G3 = 1; p = 0.88). Janaguba had an effect on the growth of mice, but had no influence on the progression of lung cancer in this model.

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Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 33%
Student > Postgraduate 1 17%
Other 1 17%
Student > Master 1 17%
Unknown 1 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 50%
Environmental Science 1 17%
Veterinary Science and Veterinary Medicine 1 17%
Unknown 1 17%