Title |
Strategies for appropriate antibiotic use in intensive care unit
|
---|---|
Published in |
Einstein (São Paulo), June 2015
|
DOI | 10.1590/s1679-45082015rw3145 |
Pubmed ID | |
Authors |
Camila Delfino Ribeiro da Silva, Moacyr Silva |
Abstract |
The comsumption of antibiotics is high, mainly in intensive care units. Unfortunately, most are inappropriately used leading to increased multi-resistant bacteria. It is well known that initial empirical therapy with broad-spectrum antibiotics reduce mortality rates. However the prolonged and irrational use of antimicrobials may also increase the risk of toxicity, drug interactions and diarrhea due to Clostridium difficile. Some strategies to rational use of antimicrobial agents include avoiding colonization treatment, de-escalation, monitoring serum levels of the agents, appropriate duration of therapy and use of biological markers. This review discusses the effectiveness of these strategies, the importance of microbiology knowledge, considering there are agents resistant to Staphylococcus aureus and Klebsiella pneumoniae, and reducing antibiotic use and bacterial resistance, with no impact on mortality. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | <1% |
Unknown | 103 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 19 | 18% |
Student > Postgraduate | 16 | 15% |
Student > Master | 14 | 13% |
Student > Ph. D. Student | 8 | 8% |
Researcher | 6 | 6% |
Other | 15 | 14% |
Unknown | 26 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 15% |
Agricultural and Biological Sciences | 12 | 12% |
Immunology and Microbiology | 4 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Other | 13 | 13% |
Unknown | 28 | 27% |