Title |
Sleep-disordered breathing in patients with cystic fibrosis*
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Published in |
Jornal de Pneumologia, January 2015
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DOI | 10.1590/s1806-37132015000004468 |
Pubmed ID | |
Authors |
Jefferson Veronezi, Ana Paula Carvalho, Claudio Ricachinewsky, Anneliese Hoffmann, Danielle Yuka Kobayashi, Otavio Bejzman Piltcher, Fernando Antonio Abreu e Silva, Denis Martinez |
Abstract |
To test the hypothesis that disease severity in patients with cystic fibrosis (CF) is correlated with an increased risk of sleep apnea. A total of 34 CF patients underwent clinical and functional evaluation, as well as portable polysomnography, spirometry, and determination of IL-1β levels. Mean apnea-hypopnea index (AHI), SpO2 on room air, and Epworth Sleepiness Scale score were 4.8 ± 2.6, 95.9 ± 1.9%, and 7.6 ± 3.8 points, respectively. Of the 34 patients, 19 were well-nourished, 6 were at nutritional risk, and 9 were malnourished. In the multivariate model to predict the AHI, the following variables remained significant: nutritional status (β = -0.386; p = 0.014); SpO2 (β = -0.453; p = 0.005), and the Epworth Sleepiness Scale score (β = 0.429; p = 0.006). The model explained 51% of the variation in the AHI. The major determinants of sleep apnea were nutritional status, SpO2, and daytime sleepiness. This knowledge not only provides an opportunity to define the clinical risk of having sleep apnea but also creates an avenue for the treatment and prevention of the disease. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 1 | 2% |
Unknown | 44 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 18% |
Other | 5 | 11% |
Student > Master | 5 | 11% |
Student > Postgraduate | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 8 | 18% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 42% |
Nursing and Health Professions | 6 | 13% |
Agricultural and Biological Sciences | 1 | 2% |
Psychology | 1 | 2% |
Sports and Recreations | 1 | 2% |
Other | 3 | 7% |
Unknown | 14 | 31% |