Title |
Imaging Alzheimer's disease pathophysiology with PET
|
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Published in |
Dementia & Neuropsychologia, January 2016
|
DOI | 10.1590/s1980-5764-2016dn1002003 |
Pubmed ID | |
Authors |
Lucas Porcello Schilling, Eduardo R. Zimmer, Monica Shin, Antoine Leuzy, Tharick A. Pascoal, Andréa L. Benedet, Wyllians Vendramini Borelli, André Palmini, Serge Gauthier, Pedro Rosa-Neto |
Abstract |
Alzheimer's disease (AD) has been reconceptualised as a dynamic pathophysiological process characterized by preclinical, mild cognitive impairment (MCI), and dementia stages. Positron emission tomography (PET) associated with various molecular imaging agents reveals numerous aspects of dementia pathophysiology, such as brain amyloidosis, tau accumulation, neuroreceptor changes, metabolism abnormalities and neuroinflammation in dementia patients. In the context of a growing shift toward presymptomatic early diagnosis and disease-modifying interventions, PET molecular imaging agents provide an unprecedented means of quantifying the AD pathophysiological process, monitoring disease progression, ascertaining whether therapies engage their respective brain molecular targets, as well as quantifying pharmacological responses. In the present study, we highlight the most important contributions of PET in describing brain molecular abnormalities in AD. |
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Venezuela, Bolivarian Republic of | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Unknown | 139 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 24 | 17% |
Student > Ph. D. Student | 20 | 14% |
Student > Master | 19 | 14% |
Researcher | 12 | 9% |
Student > Doctoral Student | 11 | 8% |
Other | 17 | 12% |
Unknown | 37 | 26% |
Readers by discipline | Count | As % |
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Neuroscience | 24 | 17% |
Medicine and Dentistry | 16 | 11% |
Biochemistry, Genetics and Molecular Biology | 12 | 9% |
Agricultural and Biological Sciences | 8 | 6% |
Chemistry | 7 | 5% |
Other | 30 | 21% |
Unknown | 43 | 31% |