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Incidence of dementia and association with APOE genotype in older Cubans

Overview of attention for article published in Dementia & Neuropsychologia, January 2014
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Title
Incidence of dementia and association with APOE genotype in older Cubans
Published in
Dementia & Neuropsychologia, January 2014
DOI 10.1590/s1980-57642014dn84000009
Pubmed ID
Authors

Juan J. Llibre Rodríguez, Adolfo Valhuerdi Cepero, Isis Y. Sanchez Gil, Ana M. López Medina, Juan C. Llibre-Guerra, Jorge J. Llibre-Guerra, Beatriz Marcheco Teruel, Cleusa P. Ferri, Martin Prince

Abstract

In an admixed population of older Cubans, the incidence and association of APOE and sociodemographic risk factors with dementia incidence was estimated. A single-phase survey (baseline) of all over 65-year-olds residing in seven catchment areas in Cuba (n=2944) was conducted between 2003 and 2007. Dementia diagnosis was established according to DSM-IV and 10/66 criteria. APOE genotype was determined in 2520 participants. An incidence wave was conducted 4.5 years after cohort inception in order to estimate incidence and associations with sociodemographic risk factors of the APOE ε4 genotype. The incidence rate of DSM IV dementia was 9.0 per 1000 person-years (95% CI 7.2-11.3) and of 10/66 dementia was 20.5 per 1000 person-years (95% CI, 17.6-23.5). Older age, a family history of dementia and APOE ε4 genotype were independent risk factors for incident 10/66 dementia. APOE genotype was associated cross-sectionally with dementia prevalence, but the effect on the incidence of dementia was attenuated, and only apparent among those in the youngest age group. The incidence of dementia in the older Cuban population is relatively high and similar to levels reported in Europe and North-America. The study showed that the relationship between APOE ε4 and incident dementia is stronger in the younger-old than the older-old and that this change must be taken into account in models of dementia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 8%
Researcher 1 8%
Student > Doctoral Student 1 8%
Unknown 10 77%
Readers by discipline Count As %
Arts and Humanities 1 8%
Nursing and Health Professions 1 8%
Neuroscience 1 8%
Unknown 10 77%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2018.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Dementia & Neuropsychologia
#239
of 328 outputs
Outputs of similar age
#202,818
of 319,271 outputs
Outputs of similar age from Dementia & Neuropsychologia
#8
of 10 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 328 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.