Title |
Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus
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Published in |
Revista Brasileira de Parasitologia Veterinária, September 2015
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DOI | 10.1590/s1984-29612015059 |
Pubmed ID | |
Authors |
Iara Tersia Freitas Macedo, Lorena Mayana Beserra de Oliveira, Wesley Lyeverton Correia Ribeiro, Jessica Maria Leite dos Santos, Kaline das Chagas Silva, José Vilemar de Araújo, Ana Lourdes Fernandes Camurça-Vasconcelos, Claudia Maria Leal Bevilaqua |
Abstract |
Parasitic nematodes are of major economic importance in livestock. An alternative for the control of parasites is phytotherapy. This study evaluated the efficacy of Cymbopogon citratus decoction (CcD), C. citratus essential oil (CcEo) and citral against Haemonchus contortus using in vitro egg hatch test (EHT) and larval development test (LDT) and an in vivo test using a Meriones unguiculatus (gerbil) model. The effect of 800 mg/kg CcEo was evaluated in gerbils that had been artificially infected with 5,000 third-stage H. contortus larvae. The effective concentrations required to inhibit 50% (EC50) of egg hatching were 0.46, 0.14 and 0.13 mg/mL for CcD, CcEo and citral, respectively. The EC50 values in the LDT were 5.04, 1.92 and 1.37 mg/mL for CcD, CcEo and citral, respectively. H. contortus population in the group treated with C. citratus essential oil was reduced by 38.5% (P< 0.05) in comparison to the control group. These results suggest that it may be possible to use C. citratusessential oil to control of H. contortus parasite of small ruminant. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 1% |
Unknown | 73 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 14% |
Student > Bachelor | 10 | 14% |
Student > Doctoral Student | 6 | 8% |
Student > Ph. D. Student | 5 | 7% |
Other | 4 | 5% |
Other | 18 | 24% |
Unknown | 21 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 22 | 30% |
Veterinary Science and Veterinary Medicine | 13 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Medicine and Dentistry | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 9 | 12% |
Unknown | 22 | 30% |