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Histopathological analysis of the therapeutic response to cryotherapy with liquid nitrogen in patients with multiple actinic keratosis*

Overview of attention for article published in Anais Brasileiros de Dermatologia, June 2015
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Title
Histopathological analysis of the therapeutic response to cryotherapy with liquid nitrogen in patients with multiple actinic keratosis*
Published in
Anais Brasileiros de Dermatologia, June 2015
DOI 10.1590/abd1806-4841.20153302
Pubmed ID
Authors

Marina Câmara de Oliveira, Flávia Trevisan, Clovis Antônio Lopes Pinto, Célia Antônia Xavier, Jaqueline Campoi Calvo Lopes Pinto

Abstract

Actinic keratoses are premalignant lesions of the skin caused by excessive sun exposure. Lesions may become mainly squamous cell carcinoma. Cryotherapy with liquid nitrogen is one of the main treatments. In order to evaluate the response of actinic keratosis to cryotherapy by histopathology, two lesions were selected in each of 14 patients with multiple actinic keratoses. In one lesion a biopsy was performed and in the other lesion a biopsy was performed after cryotherapy. Subsequently, both biopsies were compared histologically. Of the thirteen patients who completed the study, the best results were obtained in lesions undergoing cryotherapy concerning the atypia of keratinocytes, epithelial thickness and corneal layer and lymphocytic infiltrate. Despite the small number of patients, it was concluded that, if performed correctly, cryotherapy has high efficacy in the treatment of actinic keratoses.

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The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 29%
Researcher 2 10%
Student > Bachelor 2 10%
Unspecified 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 8 38%
Readers by discipline Count As %
Medicine and Dentistry 7 33%
Unspecified 1 5%
Nursing and Health Professions 1 5%
Business, Management and Accounting 1 5%
Agricultural and Biological Sciences 1 5%
Other 1 5%
Unknown 9 43%