Anti-TNF-α and hydralazine drug-induced lupus*

Maria Victória Quaresma, Fred Bernardes, Fernanda Brandão de Oliveira, Mercedes Prates Pockstaller, Maria Fernanda Reis Gavazzoni Dias, David Rubem Azulay

Drug-induced lupus is a rare drug reaction featuring the same symptoms as idiopathic lupus erythematosus. Recently, with the introduction of new medicines in clinical practice, an increase in the number of illness-triggering implicated drugs has been reported, with special emphasis on anti-TNF-α drugs. In the up-to-date list, almost one hundred medications have been associated with the occurrence of drug-induced lupus. The authors present two case reports of the illness induced respectively by hydralazine and infliximab, addressing the clinical and laboratorial characteristics, diagnosis, and treatment.