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Capsiate treatment in liver surgeries may compromise its recovery1

Overview of attention for article published in Acta Cirúrgica Brasileira, May 2018
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Title
Capsiate treatment in liver surgeries may compromise its recovery1
Published in
Acta Cirúrgica Brasileira, May 2018
DOI 10.1590/s0102-865020180050000006
Pubmed ID
Authors

Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes

Abstract

To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH. Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations. Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery.

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Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Student > Master 2 33%
Other 1 17%
Unknown 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Nursing and Health Professions 1 17%
Pharmacology, Toxicology and Pharmaceutical Science 1 17%
Unknown 2 33%