Title |
Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era
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Published in |
Revista do Instituto de Medicina Tropical de Sao Paulo, August 2017
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DOI | 10.1590/s1678-9946201759044 |
Pubmed ID | |
Authors |
Pâmela Cristina Mastellaro Delvas Zanni, Patrícia de Souza Bonfim-Mendonça, Melyssa Negri, Sandra Sayuri Nakamura, Lucélia Donatti, Terezinha Inez Estivalet Svidzinski, Márcia Edilaine Lopes Consolaro |
Abstract |
Vulvovaginal candidiasis (VVC) in HIV-infected (HIV+) women is a serious public health problem. However, little is known about the virulence mechanisms of vaginal Candida albicans from HIV+ women in the post-highly active antiretroviral therapy (HAART) era. Here, we report a comparative analysis of the expression of key virulence factors and genetic variability of 26 vaginal C. albicans strains isolated from HIV+ women undergoing HAART and 18 from HIV-uninfected (HIV-) women. In general, we observed that C. albicans from HIV+ women receiving HAART showed lower expression of virulence factors compared with C. albicans from HIV- women, except for the proteinase activity which is highly expressed. The results in HIV-women further suggest that virulence factors appear to be expressed in response to the yeast stress, in the presence of an adequate immune response. Furthermore, the RAPD results showed a high heterogeneity among isolates from both groups of women. These findings in HIV+ women using HAART will help to improve the monitoring of vaginal yeast infections and the quality of life of patients. |
X Demographics
Geographical breakdown
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 23% |
Student > Doctoral Student | 6 | 15% |
Student > Master | 3 | 8% |
Other | 2 | 5% |
Student > Ph. D. Student | 2 | 5% |
Other | 3 | 8% |
Unknown | 15 | 38% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 20% |
Immunology and Microbiology | 6 | 15% |
Medicine and Dentistry | 4 | 10% |
Agricultural and Biological Sciences | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 18 | 45% |