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Piper aduncum against Haemonchus contortus isolates: cross resistance and the research of natural bioactive compounds

Overview of attention for article published in Revista Brasileira de Parasitologia Veterinária, December 2016
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Title
Piper aduncum against Haemonchus contortus isolates: cross resistance and the research of natural bioactive compounds
Published in
Revista Brasileira de Parasitologia Veterinária, December 2016
DOI 10.1590/s1984-29612016073
Pubmed ID
Authors

Yousmel Alemán Gaínza, Rafaela Regina Fantatto, Francisco Celio Maia Chaves, Humberto Ribeiro Bizzo, Sérgio Novita Esteves, Ana Carolina de Souza Chagas

Abstract

The anthelminthic activity of the essential oil (EO) of Piper aduncum L. was tested in vitro on eggs and larvae of resistant (Embrapa2010) and susceptible (McMaster) isolates of Haemonchus contortus. The EO was obtained by steam distillation and its components identified by chromatography. EO concentrations of 12.5 to 0.02 mg/mL were used in the egg hatch test (EHT) and concentrations of 3.12 to 0.01 mg/mL in the larval development test (LDT). Inhibition concentrations (IC) were determined by the SAS Probit procedure, and significant differences assessed by ANOVA followed by Tukey's test. In the EHT, the IC50 for the susceptible isolate was 5.72 mg/mL. In the LDT, the IC50 and IC90 were, respectively, 0.10 mg/mL and 0.34 mg/mL for the susceptible isolate, and 0.22 mg/mL and 0.51 mg/mL for the resistant isolate. The EO (dillapiole 76.2%) was highly efficacious on phase L1. Due to the higher ICs obtained for the resistant isolate, it was raised the hypothesis that dillapiole may have a mechanism of action that resembles those of other anthelmintic compounds. We further review and discuss studies, especially those conducted in Brazil, that quantified the major constituents of P. aduncum-derived EO.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 14%
Lecturer 2 10%
Professor 1 5%
Researcher 1 5%
Unknown 14 67%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Arts and Humanities 1 5%
Veterinary Science and Veterinary Medicine 1 5%
Environmental Science 1 5%
Other 0 0%
Unknown 13 62%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2018.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Revista Brasileira de Parasitologia Veterinária
#294
of 660 outputs
Outputs of similar age
#297,831
of 416,449 outputs
Outputs of similar age from Revista Brasileira de Parasitologia Veterinária
#4
of 12 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 660 research outputs from this source. They receive a mean Attention Score of 1.2. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,449 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.