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X Demographics
Mendeley readers
Attention Score in Context
| Title |
High-sugar diet leads to obesity and metabolic diseases in ad libitum -fed rats irrespective of caloric intake
|
|---|---|
| Published in |
Archives of Endocrinology and Metabolism, March 2020
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| DOI | 10.20945/2359-3997000000199 |
| Pubmed ID | |
| Authors |
Daiane Teixeira de Oliveira, Isabela da Costa Fernandes, Graziele Galdino de Sousa, Talita Adriana Pereira Dos Santos, Nívia Carolina Nogueira de Paiva, Cláudia Martins Carneiro, Elísio Alberto Evangelista, Natália Rocha Barboza, Renata Guerra-Sá |
| Abstract |
Objective Provide a comprehensive view of the events surrounding the sugar consumption, under conditions of energy equivalence; through the analysis of behavioral aspects of intake, and of biochemical, metabolic and physiological parameters, as well as the effect of this nutrient on the plasticity of adipose tissue. Materials and methods Newly weaned male Wistar rats were classified in two groups and subjected to the following normocaloric diets: standard chow diet or to high-sugar diet (HSD) ad libitum for 18 weeks. Results The animals submitted to the HSD were associated with a lower caloric intake during the 18 weeks of experimentation. However, the HSD induced a significant increase in body weight, white adipose tissue weight, adiposity index, Lee index, and the levels of triglycerides and very low-density lipoprotein in the serum. In addition, it induced glucose intolerance, insulin resistance and compensatory increase of insulin secretion by pancreatic β-cells. Also increased heart rate and induced hyperplasia, and hypertrophy of retroperitoneal visceral adipose tissue. In the liver, the HSD was associated with increased hepatic lipid content (i.e., triglycerides and cholesterol) and hepatomegaly. Conclusion The post-weaning consumption of HSD induces an adaptive response in metabolism; however, such an event is not enough to reverse the homeostatic imbalance triggered by the chronic consumption of this macronutrient, leading to the development of metabolic syndrome, irrespective of caloric intake. These findings corroborate recent evidence indicating that sugar is a direct contributor to metabolic diseases independent of a positive energy balance. Arch Endocrinol Metab. 2020;64(1):71-81. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Latvia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 14% |
| Student > Master | 5 | 11% |
| Student > Ph. D. Student | 4 | 9% |
| Professor > Associate Professor | 2 | 5% |
| Other | 2 | 5% |
| Other | 4 | 9% |
| Unknown | 21 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 14% |
| Medicine and Dentistry | 4 | 9% |
| Nursing and Health Professions | 3 | 7% |
| Veterinary Science and Veterinary Medicine | 2 | 5% |
| Materials Science | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 24 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2020.
All research outputs
#16,278,775
of 25,706,302 outputs
Outputs from Archives of Endocrinology and Metabolism
#305
of 803 outputs
Outputs of similar age
#223,805
of 391,090 outputs
Outputs of similar age from Archives of Endocrinology and Metabolism
#6
of 18 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 803 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 391,090 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.