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Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis

Overview of attention for article published in Salud Pública de México, January 2017
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Title
Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis
Published in
Salud Pública de México, January 2017
DOI 10.21149/7824
Pubmed ID
Authors

Romina A Tejada, Kris G Vargas, Vicente Benites-Zapata, Edward Mezones-Holguín, Rafael Bolaños-Díaz, Adrián V Hernandez

Abstract

To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 95 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 15%
Student > Master 11 11%
Researcher 10 10%
Student > Ph. D. Student 7 7%
Student > Doctoral Student 5 5%
Other 17 18%
Unknown 32 33%
Readers by discipline Count As %
Medicine and Dentistry 27 28%
Nursing and Health Professions 5 5%
Immunology and Microbiology 4 4%
Agricultural and Biological Sciences 4 4%
Business, Management and Accounting 3 3%
Other 17 18%
Unknown 36 38%