Title |
Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis
|
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Published in |
Salud Pública de México, January 2017
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DOI | 10.21149/7824 |
Pubmed ID | |
Authors |
Romina A Tejada, Kris G Vargas, Vicente Benites-Zapata, Edward Mezones-Holguín, Rafael Bolaños-Díaz, Adrián V Hernandez |
Abstract |
To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. HPV quadrivalent vaccine is efficacious in preventing AGW in men and women. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 2 | 50% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Unknown | 95 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 15% |
Student > Master | 11 | 11% |
Researcher | 10 | 10% |
Student > Ph. D. Student | 7 | 7% |
Student > Doctoral Student | 5 | 5% |
Other | 17 | 18% |
Unknown | 32 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 28% |
Nursing and Health Professions | 5 | 5% |
Immunology and Microbiology | 4 | 4% |
Agricultural and Biological Sciences | 4 | 4% |
Business, Management and Accounting | 3 | 3% |
Other | 17 | 18% |
Unknown | 36 | 38% |