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Antioxidant capacity total in non-melanoma skin cancer and its relationship with food consumption of antioxidant nutrients.

Overview of attention for article published in Nutrición Hospitalaria, April 2015
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Title
Antioxidant capacity total in non-melanoma skin cancer and its relationship with food consumption of antioxidant nutrients.
Published in
Nutrición Hospitalaria, April 2015
DOI 10.3305/nh.2015.31.4.8331
Pubmed ID
Authors

Betânia e Silva de Almendra Freitas, Laís Lima de Castro, Jordana Rayane Sousa Aguiar, Camila Guedes Borges de Araújo, Marília Berlofa Visacri, Bruna Taliani Tuan, Eder de Carvalho Pincinato, Patricia Moriel

Abstract

The non-melanoma skin cancer is the most common cancer and accounts for more than half of the diagnoses of cancer, and basal cell carcinoma (BCC), the most frequent cutaneous neoplasm, corresponding to 70-80% of cutaneous tumors. Oxidative stress is an important trigger for skin carcinogenesis. Thus, it is important to evaluate oxidative stress, in order to discern effective therapeutic strategies able to stop it or attenuate it, thereby prevent the installation of non-melanoma skin cancer. Cross-sectional study with controls, involving 84 individuals of both sexes aged between 38-84 years, divided into two groups: control group of healthy people(n = 24) and the case group included individuals who presented non-melanoma skin and they have undergoing surgery (n = 60). The blood samples of the individuals were obtained for evaluation of biomarkers of oxidative stress (F2-isoprostane, nitrite, thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity). The usual dietary intake and nutritional status of the subjects were evaluated. The significance level for this study was 5%. Patients in the case group had higher serum concentrations of biomarkers of oxidative stress, F2-isoprostane concentrations were significantly higher compared to controls. The results showed high rates of overweight and obesity in the case and control groups. The dietary concentrations of antioxidant minerals zinc, copper and selenium in the case group were significantly lower compared to controls. The correlation between markers of oxidative stress and dietary concentrations of antioxidant nutrients showed the influence of food intake of vitamins A and E in reducing oxidative stress, since these nutrients behave as important antioxidants, acting as sweepers of RL, by removing of the body the negative effects on the redox balance of the skin. We emphasize the importance of adopting healthy eating habits that optimize the consumption of antioxidant nutrients as a strategy to prevent oxidative damage to the skin.

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Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 13%
Student > Ph. D. Student 2 8%
Student > Bachelor 2 8%
Lecturer 1 4%
Unknown 16 67%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Medicine and Dentistry 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Chemical Engineering 1 4%
Agricultural and Biological Sciences 1 4%
Other 1 4%
Unknown 16 67%