Title |
Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study
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Published in |
Jornal de Pneumologia, April 2021
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DOI | 10.36416/1806-3756/e20200166 |
Pubmed ID | |
Authors |
Augusto Hasiak Santo, Luiz Vicente Ribeiro Ferreira da Silva-Filho |
Abstract |
To describe causes of death and mortality data related to cystic fibrosis (CF) using a multiple-cause-of-death methodology. Annual mortality data for the 1999-2017 period were extracted from the Brazilian National Ministry of Health Mortality Database. All death certificates in which category E84 (CF) of the ICD-10, was listed as an underlying or associated cause of death were selected. Epidemiological and clinical data were described, and standardized mortality rates were calculated per year and for the 2000-2017 period. A joinpoint regression analysis was performed to detect changes in the mortality rates during the study period. Overall, 2,854 CF-related deaths were identified during the study period, ranging from 68 in 1999 to 289 in 2017. CF was the underlying cause of death in 83.5% of the death certificates. A continuous upward trend in the death rates was observed, with a significant annual percent change of 6.84% (5.3-8.4%) among males and 7.50% (6.6-8.4%) among females. The median age at death increased from 7.5 years in 1999 to 56.5 years in 2017. Diseases of the respiratory system accounted for 77% of the associated causes in the death certificates that reported CF as the underlying cause of death. A significant and continuous increase in CF-related death rates was found in Brazil in the last years, as well as a concurrent increase in the median age at death. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 26% |
Student > Doctoral Student | 1 | 5% |
Student > Master | 1 | 5% |
Unknown | 12 | 63% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 16% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Earth and Planetary Sciences | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Unknown | 13 | 68% |