Title |
Bases moleculares de la resistencia a meticilina en Staphylococcus aureus
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Published in |
Revista chilena de infectología, January 2018
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DOI | 10.4067/s0716-10182018000100007 |
Pubmed ID | |
Authors |
Alejandro Aguayo-Reyes, Mario Quezada-Aguiluz, Sergio Mella, Gisela Riedel, Andrés Opazo-Capurro, Helia Bello-Toledo, Mariana Domínguez, Gerardo González-Rocha |
Abstract |
Staphylococcus aureus isolates resistant to several antimicrobials have been gradually emerged since the beginning of the antibiotic era. Consequently, the first isolation of methicillin-resistant S. aureus occurred in 1960, which was described a few years later in Chile. Currently, S. aureus resistant to antistaphylococcal penicillins is endemic in Chilean hospitals and worldwide, being responsible for a high burden of morbidity and mortality. This resistance is mediated by the expression of a new transpeptidase, named PBP2a or PBP2', which possesses lower affinity for the β-lactam antibiotics, allowing the synthesis of peptidoglycan even in presence of these antimicrobial agents. This new enzyme is encoded by the mecA gene, itself embedded in a chromosomal cassette displaying a genomic island structure, of which there are several types and subtypes. Methicillin resistance is mainly regulated by an induction mechanism activated in the presence of β-lactams, through a membrane receptor and a repressor of the gene expression. Although mec-independent methicillin resistance mechanisms have been described, they are clearly infrequent. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 193 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 42 | 22% |
Student > Master | 11 | 6% |
Student > Doctoral Student | 10 | 5% |
Other | 9 | 5% |
Researcher | 9 | 5% |
Other | 24 | 12% |
Unknown | 88 | 46% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 16% |
Biochemistry, Genetics and Molecular Biology | 21 | 11% |
Immunology and Microbiology | 14 | 7% |
Agricultural and Biological Sciences | 9 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 19 | 10% |
Unknown | 94 | 49% |