Title |
Microorganismos aislados de hemocultivos en nios con cncer y neutropenia febril de alto riesgo en cinco hospitales de Santiago, Chile, perodo 2012-2015
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Published in |
Revista chilena de infectología, April 2018
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DOI | 10.4067/s0716-10182018000200140 |
Pubmed ID | |
Authors |
M Eliana Maldonado, Mirta Acuña, Ana M Álvarez, Carmen L Avilés, Verónica de la Maza, Carmen Salgado, Juan Tordecilla, Mónica Varas, Marcela Venegas, Milena Villarroel, Marcela Zubieta, M Elena Santolaya |
Abstract |
Microorganisms isolated from blood cultures (BC) in patients with febrile neutropenia (NF) vary over time, requiring systematic monitoring to guide appropriate empirical therapy. To identify microorganisms isolated from BC and their antimicrobial resistance profile in children with cancer and high risk NF. Prospective, multicenter study. The analysis included episodes of high-risk FN with positive BC in children under 18 years of age treated in five hospitals in Santiago, Chile, 2012-2015. A total of 206 microorganisms were analyzed in 185 episodes of high-risk FN. The main isolates were Gram negative bacilli (46.6%) and Gram positive cocci (45.1%) and the most frequent microorganisms were Escherichia coli (22.8%), coagulase negative Staphylococcus (18.0%) and Klebsiella spp. (16.5%). Escherichia coli and Klebsiella spp showed 4.2% and 67.6% resistance to third generation cephalosporins (cefotaxime/ceftriaxone), 10.6% and 40.6% resistance to fluoroquinolones (ciprofloxacin) and 2.1% and 26.5% to amikacin, respectively. Coagulase negative Staphylococcus and Staphylococcus aureus had 86.4% and 22.2% resistance to oxacillin, Streptococcus viridans group had 71% resistance to penicillin. This study updates the etiology and resistance profile of microorganisms isolated in BC from children with cancer and high risk FN, an essential tool for the adequate management of these patients. |
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Australia | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 17% |
Librarian | 2 | 9% |
Other | 2 | 9% |
Researcher | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Other | 4 | 17% |
Unknown | 7 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 26% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Immunology and Microbiology | 2 | 9% |
Nursing and Health Professions | 2 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 3 | 13% |
Unknown | 5 | 22% |