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| Title |
Signaling pathway-focused gene expression profiling in pressure overloaded hearts.
|
|---|---|
| Published in |
Annali dell'Istituto Superiore di Sanità, January 2011
|
| DOI | 10.4415/ann_11_03_09 |
| Pubmed ID | |
| Authors |
Marco Musumeci, Sonia Maccari, Elisa Corritore, Alessia Massimi, Tonino Stati, Giuseppe Marano, Liviana Catalano |
| Abstract |
The β-blocker propranolol displays antihypertrophic and antifibrotic properties in the heart subjected to pressure overload. Yet the underlying mechanisms responsible for these important effects remain to be completely understood. The purpose of this study was to determine signaling pathway-focused gene expression profile associated with the antihypertrophic action of propranolol in pressure overloaded hearts. To address this question, a focused real-time PCR array was used to screen left ventricular RNA expression of 84 gene transcripts representative of 18 different signaling pathways in C57BL/6 mice subjected to transverse aortic constriction (TAC) or sham surgery. On the surgery day, mice received either propranolol (80 mg/kg/day) or vehicle for 14 days. TAC caused a 49% increase in the left ventricular weight-to-body weight (LVW/BW) ratio without changing gene expression. Propranolol blunted LVW/BW ratio increase by approximately 50% while causing about a 3-fold increase in the expression of two genes, namely Brca1 and Cdkn2a, belonging to the TGF-beta and estrogen pathways, respectively. In conclusion, after 2 weeks of pressure overload, TAC hearts show a gene expression profile superimposable to that of sham hearts. Conversely, propranolol treatment is associated with an increased expression of genes which negatively regulate cell cycle progression. It remains to be established whether a mechanistic link between gene expression changes and the antihypertrophic action of propranolol occurs. |
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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2011.
All research outputs
#20,660,571
of 25,377,790 outputs
Outputs from Annali dell'Istituto Superiore di Sanità
#187
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Outputs of similar age
#170,837
of 190,502 outputs
Outputs of similar age from Annali dell'Istituto Superiore di Sanità
#15
of 20 outputs
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So far Altmetric has tracked 279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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