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NGF and therapeutic prospective: what have we learned from the NGF transgenic models?

Overview of attention for article published in Annali dell'Istituto Superiore di Sanità, January 2015
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Title
NGF and therapeutic prospective: what have we learned from the NGF transgenic models?
Published in
Annali dell'Istituto Superiore di Sanità, January 2015
DOI 10.4415/ann_15_01_03
Pubmed ID
Authors

Luigi Aloe, Maria Luisa Rocco

Abstract

It has been shown that topical nerve growth factor (NGF) administration induces healing action on human cutaneous, corneal and pressure ulcers, glaucoma, maculopathy and retinitis pigmentosa suggesting a therapeutic potential of NGF in human ophthalmology and cutaneous ulcers. A similar therapeutic suggestion has emerged for the NGF gene therapy of Alzheimer's disease and ischemic heart injury. Moreover, over the last few years, the role and biological properties of NGF have also been investigated with transgenic mice over-expressing and down-expressing NGF. However, the results obtained with these transgenic mice seem suitable to confirm and/or support the evidence obtained with exogenous administration of NGF regarding the suggested clinical potentiality of NGF. The aim of the present brief review is to report and comment on these two different findings of NGF's healing properties.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 19%
Student > Master 3 14%
Researcher 3 14%
Unspecified 2 10%
Student > Doctoral Student 2 10%
Other 2 10%
Unknown 5 24%
Readers by discipline Count As %
Unspecified 2 10%
Neuroscience 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Medicine and Dentistry 2 10%
Other 5 24%
Unknown 6 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2015.
All research outputs
#17,289,387
of 25,382,440 outputs
Outputs from Annali dell'Istituto Superiore di Sanità
#141
of 279 outputs
Outputs of similar age
#220,199
of 359,549 outputs
Outputs of similar age from Annali dell'Istituto Superiore di Sanità
#9
of 17 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,549 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.