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Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Overview of attention for article published in Arquivos Brasileiros de Oftalmologia, January 2016
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Title
Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits
Published in
Arquivos Brasileiros de Oftalmologia, January 2016
DOI 10.5935/0004-2749.20160010
Pubmed ID
Authors

Amália Turner Giannico, Leandro Lima, Gillian C. Shaw, Heloisa H. A. Russ, Tilde Rodrigues Froes, Fabiano Montiani-Ferreira

Abstract

The aim of this study was to investigate the effects of prostaglandin analogs on blood flow in the ophthalmic artery of clinically healthy rabbits. Fifty-five clinically healthy New Zealand white rabbits were divided into six groups, and the left eyes were treated for four weeks with the preservative benzalkonium chloride (BAK) only or a topical formulation of different prostaglandin analogs (bimatoprost BAK, tafluprost BAK-free, travoprost BAK, travoprost POLYQUAD, and latanoprost BAK). Color Doppler imaging was performed before and after the treatments. The mean values of the peak systolic velocity (PSV) and end diastolic velocity and the resistive index (RI) were calculated. Statistical analysis was performed to compare the differences pre- and post-treatment for each drug and post-treatment among the drugs. The prostaglandin analogs did not affect PSV. Bimatoprost BAK, travoprost POLYQUAD, and latanoprost BAK did not change RI. Tafluprost BAK-free and travoprost BAK therapy resulted in similar reductions in RI. No significant differences pre- and post-treatment were found when BAK was administered alone. The prostaglandin analogs tafluprost BAK-free and travoprost BAK improved blood flow in the ophthalmic artery in healthy New Zealand white rabbits, which suggests that these drugs enhance the prevention of the progression the progression of glaucoma.

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Mendeley readers

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The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Student > Master 3 19%
Student > Bachelor 1 6%
Lecturer > Senior Lecturer 1 6%
Other 1 6%
Other 1 6%
Unknown 5 31%
Readers by discipline Count As %
Medicine and Dentistry 4 25%
Veterinary Science and Veterinary Medicine 3 19%
Nursing and Health Professions 1 6%
Social Sciences 1 6%
Computer Science 1 6%
Other 2 13%
Unknown 4 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2016.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Arquivos Brasileiros de Oftalmologia
#322
of 446 outputs
Outputs of similar age
#341,828
of 399,677 outputs
Outputs of similar age from Arquivos Brasileiros de Oftalmologia
#33
of 43 outputs
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