Biomarcadores da injúria renal aguda

Luis Alberto Batista Peres, Ademar Dantas da Cunha Júnior, Alex Júnior Schäfer, Aline Liene da Silva, Arianne Ditzel Gaspar, Deborah Francisca Scarpari, Julia Barazetti Ferrari Alves, Rodolfo Girelli Neto, Thaís Figueiredo Teodoro de Oliveira

Creatinine remains the standard for laboratory diagnosis of AKI. Efforts to prevent nephrotoxicity have been harmed by the delay in the diagnosis of AKI criteria by using only the creatinine as a marker, therefore there is great interest in identifying early reliable biomarkers. Moreover, early treatment of ARF can be correlated with a better prognosis and identification of biomarkers for early diagnosis would improve the efficacy of a therapeutic strategy. Thus, it becomes imperative to find biomarkers that can stratify correctly the extent of renal damage that each patient has suffered and the risk of developing chronic kidney disease (CKD). Here, we review the main features of emerging biomarkers in nephrology.