Title |
Efeito de doses elevadas de vitamina D3 associada à suplementação de cálcio em modelo experimental de nefrolitíase
|
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Published in |
Jornal Brasileiro de Nefrologia, January 2014
|
DOI | 10.5935/0101-2800.20140022 |
Pubmed ID | |
Authors |
Maria Fátima de Paula Ramos, Luciane Gomes de Santana, Clara Versolato Rasvickas, Vicente de Paulo Castro Teixeira, Nestor Schor |
Abstract |
Introduction: There is little information in the literature relating supplementary oral usage of vitamin D and calcium to the development of kidney stones. Objective: To evaluate the effect of high dose, 200 IU of vitamin D3 (V) with calcium supplementation (Ca). Methods: Experimental model consists of insertion of pellets into the bladder of rats. V was administered for 30 days with or without Ca. The rats were divided in 6 groups: 1. Sham, 2. Pellets control; 3. V control; 4. Pellets + V; 5. Pellets + Ca and 6. Pellets + Ca + V. Results: 50% and 17% decreases bladder stones formation in groups 5 and 6, p < 0.005 comparing with the group 2 were observed. There was no hypercalcemia or hypercalciuria in all groups. We observed a significant decrease in calciuria in group 6 (p = 0.03). Conclusion: The administration of the V associated with Ca significantly decreased the formation of stones and caused a significant reduction in urinary calcium, suggesting a protection in the lithogenic pathophysiology. |
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