Title |
When kidneys get old: an essay on nephro-geriatrics
|
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Published in |
Jornal Brasileiro de Nefrologia, January 2017
|
DOI | 10.5935/0101-2800.20170010 |
Pubmed ID | |
Authors |
Richard Glassock, Aleksandar Denic, Andrew D. Rule |
Abstract |
Aging is a nearly universal phenomenon in biology only partially controlled by genetic endowment. Individuals and their organs age at varying rates. The kidneys manifest the aging process by steady loss of nephrons and a corresponding decrease in glomerular filtration rate (GFR) beginning about age 30 years. The mechanisms responsible for this observation is are elusive. However, defining chronic kidney disease based on arbitrary, fixed thresholds of GFR in the later phases of life can be problematical as it may over-diagnosis CKD in the elderly. A modest, persisting reduction of GFR (around 45-59 ml/min/1.73m2) without abnormal proteinuria does not seem to confer much of an adverse effect on mortality and remaining life expectancy in older adults and the development of end-stage renal disease in such subjects is very uncommon. Old kidneys should not be equated with "diseased" kidneys. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 11 | 19% |
Professor | 6 | 10% |
Researcher | 6 | 10% |
Student > Master | 4 | 7% |
Student > Ph. D. Student | 2 | 3% |
Other | 6 | 10% |
Unknown | 23 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 34% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Unspecified | 2 | 3% |
Nursing and Health Professions | 2 | 3% |
Other | 3 | 5% |
Unknown | 25 | 43% |