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Schistosoma mansoni associated glomerulopathy with IgA mesangial deposits: case report

Overview of attention for article published in Jornal Brasileiro de Nefrologia, January 2017
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Title
Schistosoma mansoni associated glomerulopathy with IgA mesangial deposits: case report
Published in
Jornal Brasileiro de Nefrologia, January 2017
DOI 10.5935/0101-2800.20170015
Pubmed ID
Authors

Fabiana Oliveira Gonçalves, Tânia Maria de Souza Fontes, Ana Paula Pereira Santana Lemes Canuto

Abstract

Renal involvement is a severe form of schistosomiasis and occurs in 10% to 15% of patients with the hepatosplenic form of the disease. Nephrotic syndrome is the most common clinical presentation. It is a complication caused by immune complexes (IC), it is rare to appear in the Brazilian context with a immunoglobulin A (IgA) deposits. When installed the renal injury by Schistosoma mansoni, classically presents as membranoproliferative glomerulonephritis (mesangiocapillary) with lobular accentuation. To report a case of schistosomiasis nephropathy that appeared 7 years after treatment of hepatosplenic schistosomiasis with histologic pattern of mesangial proliferative glomerulonephritis with IgA deposits in mesangium. Clinically developed with progressive decrease of proteinuria with angiotensin receptor blocker (ARB). It was reported a case of a 36 years old patient, brown, with classical sintoms of nephrotic syndrome (proteinuria > 3.5 g/24h, hypoalbuminemia and hypercholesterolemia), however with hepatosplenic schistosomiasis history 7 years ago and portal hypertension. Patient underwent renal biopsy which showed IgA deposits in mesangial, being more intense than immunoglobulin G (IgG), accompanied by C1q and C3, with 4/13 glomeruli sclerotic, standard light mesangial glomerulonephritis renal injury with IgA deposits. Patient began taking ARB with progressive improvement in proteinuria. Patients with glomerulonephritis by schistosoma don't show improvement of disease progression with antiparasitic treatment. However the anti-proteinuric treatment can slow the progression of end stage kidney disease.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 28%
Librarian 4 22%
Professor 2 11%
Student > Ph. D. Student 1 6%
Other 1 6%
Other 0 0%
Unknown 5 28%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Nursing and Health Professions 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Immunology and Microbiology 1 6%
Other 1 6%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2018.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Jornal Brasileiro de Nefrologia
#307
of 365 outputs
Outputs of similar age
#362,560
of 421,709 outputs
Outputs of similar age from Jornal Brasileiro de Nefrologia
#21
of 24 outputs
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So far Altmetric has tracked 365 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.