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Sedation protocols versus daily sedation interruption: a systematic review and meta-analysis

Overview of attention for article published in Revista Brasileira de Terapia Intensiva, January 2016
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Title
Sedation protocols versus daily sedation interruption: a systematic review and meta-analysis
Published in
Revista Brasileira de Terapia Intensiva, January 2016
DOI 10.5935/0103-507x.20160078
Pubmed ID
Authors

Antonio Paulo Nassar, Marcelo Park

Abstract

The aim of this study was to systematically review studies that compared a mild target sedation protocol with daily sedation interruption and to perform a meta-analysis with the data presented in these studies. We searched Medline, Scopus and Web of Science databases to identify randomized clinical trials comparing sedation protocols with daily sedation interruption in critically ill patients requiring mechanical ventilation. The primary outcome was mortality in the intensive care unit. Seven studies were included, with a total of 892 patients. Mortality in the intensive care unit did not differ between the sedation protocol and daily sedation interruption groups (odds ratio [OR] = 0.81; 95% confidence interval [CI] 0.60 - 1.10; I2 = 0%). Hospital mortality, duration of mechanical ventilation, intensive care unit and hospital length of stay did not differ between the groups either. Sedation protocols were associated with an increase in the number of days free of mechanical ventilation (mean difference = 6.70 days; 95%CI 1.09 - 12.31 days; I2 = 87.2%) and a shorter duration of hospital length of stay (mean difference = -5.05 days, 95%CI -9.98 - -0.11 days; I2 = 69%). There were no differences in regard to accidental extubation, extubation failure and the occurrence of delirium. Sedation protocols and daily sedation interruption do not appear to differ in regard to the majority of analyzed outcomes. The only differences found were small and had a high degree of heterogeneity.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 21%
Student > Bachelor 12 15%
Other 8 10%
Student > Postgraduate 7 9%
Researcher 6 8%
Other 13 16%
Unknown 17 21%
Readers by discipline Count As %
Nursing and Health Professions 28 35%
Medicine and Dentistry 28 35%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Biochemistry, Genetics and Molecular Biology 2 3%
Computer Science 1 1%
Other 2 3%
Unknown 16 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2017.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Revista Brasileira de Terapia Intensiva
#282
of 350 outputs
Outputs of similar age
#341,814
of 399,679 outputs
Outputs of similar age from Revista Brasileira de Terapia Intensiva
#16
of 25 outputs
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So far Altmetric has tracked 350 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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