Title |
Obesity does not Lead to Imbalance Between Myocardial Phospholamban Phosphorylation and Dephosphorylation
|
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Published in |
Arquivos Brasileiros de Cardiologia, July 2014
|
DOI | 10.5935/abc.20140083 |
Pubmed ID | |
Authors |
Paula Paccielli Freire, Carlos Augusto Barnabe Alves, Adriana Fernandes de Deus, Ana Paula Lima Leopoldo, André Soares Leopoldo, Danielle Cristina Tomaz da Silva, Loreta Casquel de Tomasi, Dijon Henrique Salomé Campos, Antonio Carlos Cicogna |
Abstract |
The activation of the beta-adrenergic system promotes G protein stimulation that, via cyclic adenosine monophosphate (cAMP), alters the structure of protein kinase A (PKA) and leads to phospholamban (PLB) phosphorylation. This protein participates in the system that controls intracellular calcium in muscle cells, and it is the primary regulator of sarcoplasmic reticulum calcium pump activity. In obesity, the beta-adrenergic system is activated by the influence of increased leptin, therefore, resulting in higher myocardial phospholamban phosphorylation via cAMP-PKA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 22% |
Student > Ph. D. Student | 5 | 19% |
Student > Master | 3 | 11% |
Professor | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 1 | 4% |
Unknown | 8 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 37% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Computer Science | 1 | 4% |
Other | 3 | 11% |
Unknown | 7 | 26% |