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Cost-Effectiveness of High, Moderate and Low-Dose Statins in the Prevention of Vascular Events in the Brazilian Public Health System

Overview of attention for article published in Arquivos Brasileiros de Cardiologia, November 2014
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Title
Cost-Effectiveness of High, Moderate and Low-Dose Statins in the Prevention of Vascular Events in the Brazilian Public Health System
Published in
Arquivos Brasileiros de Cardiologia, November 2014
DOI 10.5935/abc.20140173
Pubmed ID
Authors

Rodrigo Antonini Ribeiro, Bruce Bartholow Duncan, Patricia Klarmann Ziegelmann, Steffan Frosi Stella, Jose Luiz da Costa Vieira, Luciane Maria Fabian Restelatto, Carisi Anne Polanczyk

Abstract

Statins have proven efficacy in the reduction of cardiovascular events, but the financial impact of its widespread use can be substantial. To conduct a cost-effectiveness analysis of three statin dosing schemes in the Brazilian Unified National Health System (SUS) perspective. We developed a Markov model to evaluate the incremental cost-effectiveness ratios (ICERs) of low, intermediate and high intensity dose regimens in secondary and four primary scenarios (5%, 10%, 15% and 20% ten-year risk) of prevention of cardiovascular events. Regimens with expected low-density lipoprotein cholesterol reduction below 30% (e.g. simvastatin 10mg) were considered as low dose; between 30-40%, (atorvastatin 10mg, simvastatin 40 mg), intermediate dose; and above 40% (atorvastatin 20-80 mg, rosuvastatin 20mg), high-dose statins. Effectiveness data were obtained from a systematic review with 136,000 patients. National data were used to estimate utilities and costs (expressed as International Dollars - Int$). A willingness-to-pay (WTP) threshold equal to the Brazilian gross domestic product per capita (circa Int$11,770) was applied. Low dose was dominated by extension in the primary prevention scenarios. In the five scenarios, the ICER of intermediate dose was below Int$10,000 per QALY. The ICER of the high versus intermediate dose comparison was above Int$27,000 per QALY in all scenarios. In the cost-effectiveness acceptability curves, intermediate dose had a probability above 50% of being cost-effective with ICERs between Int$ 9,000-20,000 per QALY in all scenarios. Considering a reasonable WTP threshold, intermediate dose statin therapy is economically attractive, and should be a priority intervention in prevention of cardiovascular events in Brazil.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Netherlands 1 1%
Brazil 1 1%
Unknown 75 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 18%
Student > Postgraduate 10 13%
Student > Ph. D. Student 7 9%
Student > Bachelor 5 6%
Researcher 5 6%
Other 11 14%
Unknown 26 33%
Readers by discipline Count As %
Medicine and Dentistry 16 21%
Pharmacology, Toxicology and Pharmaceutical Science 9 12%
Nursing and Health Professions 4 5%
Social Sciences 4 5%
Agricultural and Biological Sciences 2 3%
Other 14 18%
Unknown 29 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2015.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Arquivos Brasileiros de Cardiologia
#820
of 1,210 outputs
Outputs of similar age
#274,615
of 369,872 outputs
Outputs of similar age from Arquivos Brasileiros de Cardiologia
#18
of 28 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,210 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,872 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.