↓ Skip to main content

Role Of MMP-2 and MMP-9 in Resistance to Drug Therapy in Patients with Resistant Hypertension

Overview of attention for article published in Arquivos Brasileiros de Cardiologia, June 2015
Altmetric Badge

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
15 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Role Of MMP-2 and MMP-9 in Resistance to Drug Therapy in Patients with Resistant Hypertension
Published in
Arquivos Brasileiros de Cardiologia, June 2015
DOI 10.5935/abc.20150060
Pubmed ID
Authors

Leandro Lacerda, Ana Paula de Faria, Vanessa Fontana, Heitor Moreno, Valéria Sandrim

Abstract

Despite the increased evidence of the important role of matrix metalloproteinases (MMP-9 and MMP‑2) in the pathophysiology of hypertension, the profile of these molecules in resistant hypertension (RHTN) remains unknown. To compare the plasma levels of MMP-9 and MMP-2 and of their tissue inhibitors (TIMP-1 and TIMP-2, respectively), as well as their MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios, between patients with controlled RHTN (CRHTN, n=41) and uncontrolled RHTN (UCRHTN, n=35). In addition, the association of those parameters with clinical characteristics, office blood pressure (BP) and arterial stiffness (determined by pulse wave velocity) was evaluate in those subgroups. This study included 76 individuals diagnosed with RHTN and submitted to physical examination, electrocardiogram, and laboratory tests to assess biochemical parameters. Similar values of MMP-9, MMP-2, TIMP-1, TIMP-2, and MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios were found in the UCRHTN and CRHTN subgroups (P>0.05). A significant correlation was found between diastolic BP (DBP) and MMP-9/TIMP-1 ratio (r=0.37; P=0.02) and DPB and MMP-2 (r=-0.40; P=0.02) in the UCRHTN subgroup. On the other hand, no correlation was observed in the CRHTN subgroup. Logistic regression models demonstrated that MMP-9, MMP-2, TIMP-1, TIMP-2 and their ratios were not associated with the lack of BP control. These findings suggest that neither MMP-2 nor MMP-9 affect BP control in RHTN subjects.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 7%
Researcher 1 7%
Student > Doctoral Student 1 7%
Unknown 12 80%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 13%
Nursing and Health Professions 1 7%
Medicine and Dentistry 1 7%
Unknown 11 73%