Title |
Role Of MMP-2 and MMP-9 in Resistance to Drug Therapy in Patients with Resistant Hypertension
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Published in |
Arquivos Brasileiros de Cardiologia, June 2015
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DOI | 10.5935/abc.20150060 |
Pubmed ID | |
Authors |
Leandro Lacerda, Ana Paula de Faria, Vanessa Fontana, Heitor Moreno, Valéria Sandrim |
Abstract |
Despite the increased evidence of the important role of matrix metalloproteinases (MMP-9 and MMP‑2) in the pathophysiology of hypertension, the profile of these molecules in resistant hypertension (RHTN) remains unknown. To compare the plasma levels of MMP-9 and MMP-2 and of their tissue inhibitors (TIMP-1 and TIMP-2, respectively), as well as their MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios, between patients with controlled RHTN (CRHTN, n=41) and uncontrolled RHTN (UCRHTN, n=35). In addition, the association of those parameters with clinical characteristics, office blood pressure (BP) and arterial stiffness (determined by pulse wave velocity) was evaluate in those subgroups. This study included 76 individuals diagnosed with RHTN and submitted to physical examination, electrocardiogram, and laboratory tests to assess biochemical parameters. Similar values of MMP-9, MMP-2, TIMP-1, TIMP-2, and MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios were found in the UCRHTN and CRHTN subgroups (P>0.05). A significant correlation was found between diastolic BP (DBP) and MMP-9/TIMP-1 ratio (r=0.37; P=0.02) and DPB and MMP-2 (r=-0.40; P=0.02) in the UCRHTN subgroup. On the other hand, no correlation was observed in the CRHTN subgroup. Logistic regression models demonstrated that MMP-9, MMP-2, TIMP-1, TIMP-2 and their ratios were not associated with the lack of BP control. These findings suggest that neither MMP-2 nor MMP-9 affect BP control in RHTN subjects. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 1 | 7% |
Researcher | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Unknown | 12 | 80% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 1 | 7% |
Unknown | 11 | 73% |