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| Title |
Echocardiographic Predictors of Worse Outcome After Cardiac Resynchronization Therapy
|
|---|---|
| Published in |
Arquivos Brasileiros de Cardiologia, September 2015
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| DOI | 10.5935/abc.20150108 |
| Pubmed ID | |
| Authors |
Eduardo Arrais Rocha, Francisca Tatiana Moreira Pereira, José Sebastião Abreu, José Wellington O. Lima, Marcelo de Paula M. Monteiro, Almino Cavalcante Rocha, Ana Rosa Pinto Quidute, Camilla Viana A. Goés, Carlos Roberto Martins Rodrigues, Maurício Ibrahim Scanavacca |
| Abstract |
Cardiac resynchronization therapy (CRT) is the recommended treatment by leading global guidelines. However, 30%-40% of selected patients are non-responders. To develop an echocardiographic model to predict cardiac death or transplantation (Tx) 1 year after CRT. Observational, prospective study, with the inclusion of 116 patients, aged 64.89 ± 11.18 years, 69.8% male, 68,1% in NYHA FC III and 31,9% in FC IV, 71.55% with left bundle-branch block, and median ejection fraction (EF) of 29%. Evaluations were made in the pre‑implantation period and 6-12 months after that, and correlated with cardiac mortality/Tx at the end of follow-up. Cox and logistic regression analyses were performed with ROC and Kaplan-Meier curves. The model was internally validated by bootstrapping. There were 29 (25%) deaths/Tx during follow-up of 34.09 ± 17.9 months. Cardiac mortality/Tx was 16.3%. In the multivariate Cox model, EF < 30%, grade III/IV diastolic dysfunction and grade III mitral regurgitation at 6‑12 months were independently related to increased cardiac mortality or Tx, with hazard ratios of 3.1, 4.63 and 7.11, respectively. The area under the ROC curve was 0.78. EF lower than 30%, severe diastolic dysfunction and severe mitral regurgitation indicate poor prognosis 1 year after CRT. The combination of two of those variables indicate the need for other treatment options. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2015.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Arquivos Brasileiros de Cardiologia
#524
of 1,210 outputs
Outputs of similar age
#166,229
of 277,643 outputs
Outputs of similar age from Arquivos Brasileiros de Cardiologia
#4
of 17 outputs
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