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Attention Score in Context
| Title |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
|
|---|---|
| Published in |
Arquivos Brasileiros de Cardiologia, October 2015
|
| DOI | 10.5935/abc.20150134 |
| Pubmed ID | |
| Authors |
Felipe Gonçalves dos Santos de Sá, Ana Paula Lima-Leopoldo, Bruno Barcellos Jacobsen, Artur Junio Togneri Ferron, Wagner Muller Estevam, Dijon Henrique Salomé Campos, Edson Castardeli, Márcia Regina Holanda da Cunha, Antonio Carlos Cicogna, André Soares Leopoldo |
| Abstract |
Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. To evaluate the association between obesity resistance and cardiac function, and the impact of obesity resistance on calcium handling. Thirty-day-old male Wistar rats were distributed into two groups, each with 54 animals: control (C; standard diet) and obese (four palatable high-fat diets) for 15 weeks. After the experimental protocol, rats consuming the high-fat diets were classified according to the adiposity index and subdivided into obesity-prone (OP) and obesity-resistant (OR). Nutritional profile, comorbidities, and cardiac remodeling were evaluated. Cardiac function was assessed by papillary muscle evaluation at baseline and after inotropic maneuvers. The high-fat diets promoted increase in body fat and adiposity index in OP rats compared with C and OR rats. Glucose, lipid, and blood pressure profiles remained unchanged in OR rats. In addition, the total heart weight and the weight of the left and right ventricles in OR rats were lower than those in OP rats, but similar to those in C rats. Baseline cardiac muscle data were similar in all rats, but myocardial responsiveness to a post-rest contraction stimulus was compromised in OP and OR rats compared with C rats. Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 1 | 11% |
| Student > Doctoral Student | 1 | 11% |
| Unknown | 7 | 78% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 11% |
| Medicine and Dentistry | 1 | 11% |
| Unknown | 7 | 78% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2015.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Arquivos Brasileiros de Cardiologia
#1,002
of 1,210 outputs
Outputs of similar age
#252,774
of 295,217 outputs
Outputs of similar age from Arquivos Brasileiros de Cardiologia
#8
of 10 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,210 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.