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Physical Exercise and Regulation of Intracellular Calcium in Cardiomyocytes of Hypertensive Rats

Overview of attention for article published in Arquivos Brasileiros de Cardiologia, July 2018
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Title
Physical Exercise and Regulation of Intracellular Calcium in Cardiomyocytes of Hypertensive Rats
Published in
Arquivos Brasileiros de Cardiologia, July 2018
DOI 10.5935/abc.20180113
Pubmed ID
Authors

Joel Alves Rodrigues, Thales Nicolau Prímola-Gomes, Leôncio Lopes Soares, Tiago Ferreira Leal, Clara Nóbrega, Danillo Laviola Pedrosa, Leonardo Mateus Teixeira Rezende, Edilamar Menezes de Oliveira, Antonio Jose Natali

Abstract

Regulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups -sedentary hypertensive (SH); trained hypertensive (TH); sedentary normotensive (SN); and trained normotensive (TN). Animals of the TH and TN groups were subjected to treadmill running program, 5 days/week, 1 hour/day at 60-70% of maximum running velocity for 8 weeks. We adopted a p ≤ 0.05 as significance level for all comparisons. Exercise training reduced systolic arterial pressure in hypertensive rats. In normotensive rats, exercise training reduced the time to 50% cell relaxation and the time to peak contraction and increased the time to 50% decay of the intracellular Ca2+ transients. In SHR, exercise increased the amplitude and reduced the time to 50% decay of Ca2+ transients. Exercise training increased the expression of miR-214 in hypertensive rats only. The aerobic training applied in this study increased the availability of intracellular Ca2+ and accelerated the sequestration of these ions in left ventricular myocytes of hypertensive rats, despite increased expression of miR-214 and maintenance of cell contractility.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 15%
Student > Bachelor 6 13%
Student > Ph. D. Student 5 11%
Student > Doctoral Student 4 9%
Researcher 4 9%
Other 5 11%
Unknown 16 34%
Readers by discipline Count As %
Sports and Recreations 7 15%
Biochemistry, Genetics and Molecular Biology 6 13%
Medicine and Dentistry 5 11%
Nursing and Health Professions 4 9%
Agricultural and Biological Sciences 3 6%
Other 3 6%
Unknown 19 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2018.
All research outputs
#22,767,715
of 25,382,440 outputs
Outputs from Arquivos Brasileiros de Cardiologia
#1,002
of 1,210 outputs
Outputs of similar age
#299,653
of 341,564 outputs
Outputs of similar age from Arquivos Brasileiros de Cardiologia
#15
of 22 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,210 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,564 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.