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Synergistic growth inhibition by sorafenib and vitamin K2 in human hepatocellular carcinoma cells

Overview of attention for article published in Clinics, January 2012
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Title
Synergistic growth inhibition by sorafenib and vitamin K2 in human hepatocellular carcinoma cells
Published in
Clinics, January 2012
DOI 10.6061/clinics/2012(09)18
Pubmed ID
Authors

Yafei Zhang, Bicheng Zhang, Anran Zhang, Yong Zhao, Jie Zhao, Jian Liu, Jianfei Gao, Dianchun Fang, Zhiguo Rao

Abstract

Sorafenib is an oral multikinase inhibitor that has been proven effective as a single-agent therapy in hepatocellular carcinoma, and there is a strong rationale for investigating its use in combination with other agents. Vitamin K2 is nearly non-toxic to humans and has been shown to inhibit the growth of hepatocellular carcinoma. In this study, we evaluated the effects of a combination of sorafenib and vitamin K2 on the growth of hepatocellular carcinoma cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 14%
Student > Master 2 14%
Student > Postgraduate 2 14%
Student > Ph. D. Student 2 14%
Other 1 7%
Other 2 14%
Unknown 3 21%
Readers by discipline Count As %
Medicine and Dentistry 5 36%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Immunology and Microbiology 1 7%
Agricultural and Biological Sciences 1 7%
Other 2 14%
Unknown 3 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2012.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Clinics
#1,001
of 1,215 outputs
Outputs of similar age
#228,486
of 250,100 outputs
Outputs of similar age from Clinics
#55
of 67 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,215 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,100 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.